CLINICAL CONDITIONS. Vascular. Cavernous Sinus Thrombosis. Topics. Thombosis of the cavernous sinus. Most commonly caused by a continguously spreading infection.. On the left another case that demonstrates that you cannot fully rely on phase contrast imaging. The signal in the vein depends on the velocity of the flowing blood and the velocity encoding by the technician. On the far left a patient with non visualization of the left transverse sinus. This could be hypoplasia, venous thrombosis or slow flow. On the contrast enhanced T1-weighted image it is obvious that the sinus fills with contrast and is patent. Dural venous sinus thrombosis is a subset of cerebral venous thrombosis, often coexisting with cortical or deep vein thrombosis, and presenting in similar fashions.. Less often sepsis (SIRS) proceeds with a high temperature of the type of continua without chills, without the formation of abscesses, but with septic damage to the endocardium, kidneys, liver, intestinal tract and other organs, with severe intoxication of the central nervous system.
Unlike MR, CT-venography virtually has no pitfalls. The only thing that you don't want to do, is to scan too early, i.e. before the veins enhance or too late, i.e. when the contrast is gone. Some advocate to do a scan like a CT-arteriography and just add 5-10 seconds delay. To be on the safe side we advocate 45-50 seconds delay after the start of contrast injection. We use at least 70 cc of contrast. Cerebral venous sinus thrombosis (CVST) is a rare form of stroke that results from thrombosis (a blood clot) of the dural venous sinuses, which drain blood from the brain On spin-echo images patent cerebral veins usually will demonstrate low signal intensity due to flow void. Flow voids are best seen on T2-weighted and FLAIR images, but can sometimes also be seen on T1-weighted images. A thrombus will manifest as absence of flow void. Although this is not a completely reliable sign, it is often one of the first things, that make you think of the possibility of venous thrombosis. The next step has to be a contrast enhanced study. Cavernous sinus thrombosis is a potentially life-threatening condition that can happen after an infection in your head. It's marked by a blood clot behind your eyes or at the base..
On the left a similar case on MR. There is a combination of vasogenic edema (red arrow), cytotoxic edema and hemorrhage (blue arrow). These findings and the location in the temporal lobe, should make you think of venous infarction due to thrombosis of the vein of Labbe. The next examination should be a contrast enhanced MR or CT to prove the diagnosis.Sinus thrombosis, or venous sinus thrombosis, is a rare type of blood clot found within the dural venous sinuses. The condition is often difficult to diagnose because symptoms vary from person to person depending on the location of the clot.The great value has presence of microbes in the blood, however, the sterility of blood cultures is not evidence against sepsis. Blood cultures for sterility should be done in the first days of the fever. Cavernous sinus thrombosis a life-threatening condition that results when a blood clot is formed in a vein associated with the cavernous sinuses In the absence of a pronounced effect of the operation on the sinus, especially when the complete removal of the thrombus from the lower part of it failed, in the next few days the internal jugular vein is ligated, the upper segment is sewn into the skin and through it a thrombus is wash out from the bulb of the jugular vein and the adjacent segment of the sinus. Operation on the jugular vein (resection of the vein) is made even with obvious signs of her thrombosis.
The first, most frequent, type of sepsis in children usually occurs without chills, with a high temperature of a constant nature. In adults, to understand the true nature of the temperature curve, it is necessary to measure the temperature every 3 hours. The pulse is frequent, small, usually corresponds to temperature. The remaining frequent pulse after a decrease in temperature is prognostically unfavorable. The patient's face is pale, often has a jaundiced or earthy tinge.The blood clot typically forms when an infection that starts in your face or head moves into your cavernous sinuses. Your body creates a blood clot to try to stop the infection from spreading. However, the clot can restrict the flow of blood from your brain, potentially damaging your brain, eyes, or nerves.In cavernous sinus thrombosis, a blood clot develops in the sinuses behind your eyes or at the bottom of your skull after an infection. The clot is meant to prevent the infection from spreading, but it often blocks the blood flow out of your brain.
On the left a T2-weighted image demonstrating papil edema and an empty sella. Continue with the sagittal T1-weighted image.Dense clot sign (3) On the left images of a patient with a hemorrhagic infarction in the temporal lobe (red arrow). Notice the dense transverse sinus due to thrombosis (blue arrows).High doses of intravenous antibiotics may be used to stop the spread of infection if it is identified as the source of the problem. Cerebral venous sinus thrombosis (CVST) is a type of stroke in which the venous channels of the brain become thrombosed, resulting in cerebral infarction in the areas.. Cavernous sinus thrombosis is a very rare, life-threatening condition that can affect adults and children.
Cerebral venous thrombosis is an important cause of stroke especially in children and young adults. It is more common than previously thought and frequently missed on initial imaging. It is a difficult diagnosis because of its nonspecific clinical presentation and subtle imaging findings. In this article we will focus on:Even less often than before, local symptoms of peri-sinus abscess, sinustrombosis, thrombophlebitis and periphlebitis of the jugular vein are noted. Finally, patients with sinus thrombosis with concomitant cerebral edema, neuromuscular encephalitis of the brain or cerebellum, hydrocephalus are more often found. These are those patients who previously spread the infected thrombosis to the veins of the meninges complicated by purulent meningitis or brain abscess leading to death. The use of antibiotics eliminated the threat of purulent meningeal and brain complications, but did not eliminate stagnant phenomena associated with sterile thrombosis.Anticoagulants are contraindicated in cases of impaired liver function, peptic ulcer and duodenal ulcer. They should not be administered during menstruation. Food should be easily digestible, rich in vitamins. Plentiful drink indicated.Dense clot sign (2) Visualization of a thrombosed cortical vein that is seen as a linear or cord-like density, is also known as the cord sign. Another term that is frequently used, is the dense vessel sign.
For suspected brain abscess the application of anticoagulants should be avoided. When treatment with anticoagulants at least once in 2–3 days to be controled prothrombin level, urinalysis (hematuria considering the possibility of that is an early sign of overdose). To reduce the possibility of thrombosis, the prothrombin level should be reduced to 35–40%. Prolonged decrease in the prothrombin level below 50–60% is unacceptable, since it leads to the appearance of spontaneous bleeding.Empty delta sign (2) On the left a case of thrombosis of the right transverse sinus and the left transverse and sigmoid sinus (arrows). There is enhancement surrounding the thrombosed hypoattenuating veins. People are usually placed on intravenous antibiotics for a minimum of three weeks, because the clot often resists penetration of the antibiotics. Dural venous sinus thrombosis (DVST) is a condition that ranges from being undiagnosed to leading to serious . Dural sinus thrombosis: sources of error in image interpretation Cavernous sinus thrombosis.pdf ppt. 1. cavernous sinus trombosis dr 12. Cavernous Sinus thrombosis Characterized by multiple cranial neuropathies Clinical..
On the left a lateral and oblique MIP image from a normal contrast-enhanced MR venography. Notice the prominent vein of Trolard (red arrow) and vein of Labbe (blue arrow). Every MR techniques has its own pitfalls as we will discuss in a moment. Contrast-enhanced MR venography has the disadvantage that you need to give contrast, but has less pitfalls.Sepsis (systemic inflammatory response syndrome, SIRS) in consequence of otitis is a common infectious disease. More often sepsis is characterized by the following triad of syndromes:On the left images of a patient with venous thrombosis, who was unconsious and did not respond to anticoagulant therapy. There is thrombosis of the superior sagittal sinus (red arrow), straight sinus (blue arrow) and transverse and sigmoid sinus (yellow arrow).Sepsis (SIRS) can develop as a result of the entry of the microbe through the sinus wall and without the formation of a clot burden (more often with acute otitis). Finally, a form of sepsis is very rare, which is caused by infection in the general circulation flow from multiple thrombosed small bony veins of the mastoid process (osteo-phlebitic piemia).
by N. Khandelwal et al AJR 2006; 187:1637-1643 In some patients dural sinus thrombosis may, even after recanalisation, lead to persisting disturbances in venous circulation. This may lead to raised intracranial CSF pressure as assessed by lumbar puncture. Clinically, these patients complain of headaches and they may have vision disturbances due to papil edema. On MRI, one may see increased CSF around the optic nerve and an empty sella. Apparently in some patients a residual stenosis persists.Here a patient with a subdural hematoma on the left side, that has spread to the region of the superior sagittal sinus (arrows). At first impression this looks like an empty delta sign.Doctors may order brain scans, including CT and MRI scans, to look for cavernous sinus thrombosis. They may also test blood or spinal fluid to check for signs of infection.Depending on what they see in the scans, they may also do a blood culture test. This involves taking a small sample of your blood and testing it for bacteria. Depending on your symptoms, your doctor may also request a cerebrospinal fluid culture to check for meningitis, which sometimes occurs alongside cavernous sinus thrombosis.
Normally veins are slightly denser than brain tissue and in some cases it is difficult to say whether it is normal or too dense. In these cases a contrast enhanced scan is necessary to solve this problem. On the left an image of a thrombosed transverse sinus and next to it a normal transverse sinus. Aderman, C. "Cavernous Sinus Thrombosis," Beth Israel Deaconess Medical Center and Harvard University, April 2011.
Venous thrombosis has a nonspecific presentation and therefore it is important to recognize subtle imaging findings and indirect signs that may indicate the presence of thrombosis. Although these findings are often present on initial scans, they are frequently detected only in retrospect. Clinically patients with venous thrombosis often present with seizures, which is not a symptom in patients with an arterial infarction.. Due to direct contact with the posterolateral wall of the mastoid process, sigmoid sinus is sometimes involved in the inflammatory process of the ear, especially since small veins of the mastoid process are infused into it.
Heavy antibiotics are used to treat CST, for at least 3-4 weeks continuously as it is caused due to infections. Blood thinners are provided to try and reduce the size of the clot these are provided intravenously (IV). Seek out treatment early in cases of sinusitis, head injury or any other infection or disease as CST is caused due to their aggravation.However, antibiotics significantly changed the symptoms and course of otogenic sepsis, which in many cases makes diagnosis difficult. In connection with the scarcity, sometimes even the absence of symptoms, the classic picture of sepsis described above with otitis is rarely found today. So, now there is often a non-temperature or subfebrile course, no chills, no symptoms of general intoxication, no meningeal symptoms. Significantly less marked leukocytosis, shift leucocyte count in the blood test.The formation of thrombus is a protective reaction to the penetration of infection, but at the same time a dangerous complication of thrombophlebitis. With a weakly virulent infection and good immunobiological reactions, the thrombus can remain sterile (there are cases of the unexpected finding of an old thrombus in the sigmoid sinus in persons on brain MR-angiography or who have died from diseases not related to the ear). However, in the predominant majority of cases, the thrombus becomes infected, often becomes inflamed and becomes the source of infection. With blood flow, infected emboli or bacteria enter the small or large circle of blood circulation.
Cavernous sinus thrombosis (CST) is the formation of thrombus (clot) within the cavernous sinus, which can either be septic or aseptic. Septic CST is a rapidly evolving.. by Phua Hwee Tang et al Ann Acad Med Singapore 2008;37:397-401 On the contrast enhanced T1 images on the left there is an area of low signal intensity within the enhancing transverse sinus. This could easily been mistaken for a central thrombus within the sinus. This however is the result of flow void. Continue with the phase contrast images.On the left images of a patient with hemorrhage in the temporal lobe. When the hemorrhagic component of the infarction is large, it may look like any other intracerebral hematoma with surrounding vasogenic edema. The clue to the diagnosis in this case is seen on the contrast enhanced image, which nicely demonstrates the filling defect in the sigmoid sinus (blue arrow).Anticoagulants are especially indicated when the venous sinuses of the skull (cavernous sinus) are involved in the thrombotic process, which are not widely available for surgical intervention, and with the extensive dissemination of thrombosis through the venous system outside the skull (innominate, subclavian veins).
Chronic dural sinus thrombosis can lead to dural arteriovenous fistula formation and to increased CSF pressure.Here the sagittal T1-weighted image demonstrating the empty sella (arrow). It is called an empty sella because the sella is mainly filled with CSF as the hypofysis is compressed downwards due to the increased intracranial pressure.
On the left bilateral parasagittal edema and subte hemorrhage in a patient with thrombosis of the superior sagittal sinus.On the left three images of a patient with venous thrombosis in the superior sagittal sinus. On the far left we see a dense vessel sign on the unenhanced CT. In the middle an image made 25 seconds after the start of the contrast injection. There is arterial enhancement and it looks as if the superior sagittal sinus enhances, but in fact what we see is the shine through of the dense thrombus. Only on the image on the right, which was made 45 seconds after contrast injection there is an empty delta sign, which proves the presence of a thrombus in the sinus.Also used anticoagulants. Anticoagulants, clot burden dissolving, promote the penetration of antibiotics in the areas of the venous system that is affected by septic thrombophlebitis, and enhance the effect of antibiotics.
First of all, is performed ear surgery (simple or general — according to the nature of otitis media). Necessarily exposed wall of sigmoid sinus. If the latter is pathologically altered, it is recommended that it be widely exposed upward and downward from a healthy-looking area.On the left a T2-weighted image with normal flow void in the right sigmoid sinus and jugular vein (blue arrow). On the left there is abnormal high signal as a result of thrombosis (red arrow). Sigmoid sinus thrombosis is disorder or condition caused by suppurative Learn about sigmoid sinus thrombosis causes, symptoms, diagnostic tests, treatment and prevention The empty delta sign is a finding that is seen on a contrast enhanced CT (CECT) and was first described in thrombosis of the superior sagittal sinus. The sign consists of a triangular area of enhancement with a relatively low-attenuating center, which is the thrombosed sinus. The likely explanation is enhancement of the rich dural venous collateral circulation surrounding the thrombosed sinus, producing the central region of low attenuation. In early thrombosis the empty delta sign may be absent and you will have to rely on non-visualization of the thrombosed vein on the CECT. The sign may be absent after two months due to recanalization within the thrombus.
Magnetic resonance angiography of the brain vessels and venous sinuses is performed with suspicion of sigmoid sinus thrombophlebitis and thrombosis.Depending on the location of metastases, may occur symptoms of certain organs damage. Pulmonary metastases often occur with chronic otitis, they proceed as a type of septic pneumonia with the formation of multiple and small abscesses, the latter being located mostly around the periphery of the lung (in the places of the final branching of the pulmonary arteries).For the prevention and treatment of lesions associated with the use of anticoagulants, vitamins K, P and ascorbic acid are indicated. Cerebral venous sinus thrombosis (CVST) is the presence of a blood clot in the dural venous sinuses, which drain blood from the brain. Symptoms may include headache, abnormal vision..
by J. Linn et al American Journal of Neuroradiology 28:946-952, May 2007 Venous infarction (5) - Edema In some cases of venous thrombosis the imaging findings can resolve completely. On the left a patient with a subcortical area of high signal intensity. The first impression was that this could be a low grade glioma. On a follow up scan the abnormalities had resolved completely. In retrospect a dense vessel sign was seen in one of the cortical veins and the diagnosis of venous thrombosis was made. The high signal intensity can be attributed to vasogenic edema due to the high venous pressure that resulted from the thrombosis.
A DAVF or dural arteriovenous fistula is an abnormal connection between dural arteries, which are branches of the external carotid with the venous sinuses. Sinus thrombosis is seen in many patients with a dural arteriovenous fistula, but the pathogenesis is still unclear (10). There are two possible mechanisms: (a) thrombophlebitis of the dural sinus may induce a dural fistula and (b) in the course of a dural fistula flow reversal may lead to thrombosis. Current classifications of DAVF focus mainly on the presence of leptomeningeal reflux related to cerebral venous hypertension leading to cerebral venous infarction or hemorrhage. Sinus thrombosis, or venous sinus thrombosis, is a rare type of blood clot found within the dural venous sinuses. The condition is often difficult to diagnose because symptoms.. Other possible effects of the stroke, such as headaches or changes in vision, can be treated by specialists.
Postoperative treatment consists in the administration of antibiotics with sulfonamides. Depending on the effect of treatment or the sensitivity of the microbe to the antibiotic, other antibiotics are additionally prescribed.The course of sepsis (SIRS) is more severe and quickly leads to death. However, the most common mixed form of sepsis — the so-called pyosepticemia.
Clot removal using catheters and other specialized equipment, antibiotics, and anticoagulation drugs are the main methods used for the treatment of venous sinus thrombosis.Since we are not that familiar with venous infarctions, we often think of them as infarctions in an atypical location or in a non-arterial distribution. However venous infarctions do have a typical distribution, as shown on the left.Cerebral venous sinus thrombosis (CVST) occurs when a blood clot forms in the brain’s venous sinusesNotice the abnormal high signal in the internal cerebral veins and straight sinus on the T1-weighted images, where there should be a low signal due to flow void. This was unlike the low signal in other sinuses. The diagnosis is bilateral infarctions in the basal ganglia due to deep cerebral venous thrombosis.
Chronic dural sinus thrombosis and related syndromes. Venous thrombosis of vein of Galen and straight sinus. Venous infarction (4) - Deep cerebral veins On the far left a.. Cavernous sinus thrombosis is a blood clot in the cavernous sinuses. It can be life-threatening. The cavernous sinuses are hollow spaces located under the brain, behind.. Thrombophlebitis of the sigmoid sinus arises most often by contact (due to the inflammatory process in the adjacent bone or perisinus abscess), much less often with blood or lymph flow (hematogenous and lymphogenous pathways with furuncles on the face).Venous infarction (2) - Superior sagittal sinus thrombosis The most frequently thrombosed venous structure is the superior sagittal sinus. Infarction is seen in 75% of cases. The abnormalities are parasagittal and frequently bilateral. Hemorrhage is seen in 60% of the cases.
The symptoms of cavernous sinus thrombosis tend to show up about 5 to 10 days after you develop an infection on your face or in your head.. A headache is a primary symptom. As the condition progresses into the central nervous system, signs of nerve dysfunction such as lowered consciousness and mental confusion may manifest. The typical symptoms of CST are: Cavernous sinus thrombosis (CST) was initially described by Bright in 1831 as a complication of epidural and subdural infections. The dural sinuses are grouped into the.. Sagittal Sinus Thrombosis — collaterals. All of the above anatomic knowledge can become very useful in evaluation of venous thrombosis
Cavernous sinus thrombosis (CST) is a rare and life-threatening condition that results when a blood clot is formed in a vein associated with the cavernous sinuses. These sinuses are a pair of hollow cavities located one behind each eye and at the base of the brain. They receive deoxygenated blood from the brain and eyes. From here, this venous blood drains out into another series of sinuses after which it is collected by veins including the internal jugular vein. Cavernous sinus thrombosis represents the single CVT which produces a characteristic clinical syndrome. Head Computed Tomography is the most frequently performed..
To contain the infection, the body's immune system creates a clot to prevent bacteria or other pathogens from spreading. The clot increases pressure inside the brain. This pressure can damage the brain and may ultimately cause death.Venous infarction (4) - Deep cerebral veins On the far left a FLAIR image demonstrating high signal in the left thalamus. When you look closely and you may have to enlarge the image to appreciate this, there is also high signal in the basal ganglia on the right. These bilateral findings should raise the suspicion of deep cerebral venous thrombosis. A sagittal CT reconstruction demonstrates a filling defect in the straight sinus and the vein of Galen (arrows). More reliable thrombosis of the bulb of the jugular vein is revealed during surgery on the sigmoid sinus (no bleeding after removal of the thrombus from the lower sinus segment).On the left reconstructed sagittal CT-images in a patient with bilateral parasagittal hemorrhage due to thrombosis of the superior sagittal sinus. The red arrow on the contrast enhanced image indicates the filling defect caused by the thrombus.Cavernous sinus thrombosis can lead to severe complications. About 1 in 3 cases are fatal, so it’s very important to tell your doctor right away if you think you have it, especially if you’ve recently had an infection.
by J van Gijn JRSM Volume 93, Number 5 Pp. 230-233 by Emil J. Y. Lee September 2002 Radiology, 224, 788-789. Abscesses can erupt into the bronchus (favorable outcome) or into the pleural cavity with the formation of purulent pleurisy. Metastases in the joint capsule can lead to ankylosis of the joints. The most favorable are metastases in the subcutaneous tissue and muscles. Clinical Significance - Cavernous Sinus Thrombosis. Cavernous sinus thrombosis (CST) refers to the formation of a clot within the cavernous sinus Local symptoms of sigmoid sinus thrombosis mostly little or not expressed. Sometimes the observed swelling and tenderness at palpation along the posterior margin of the mastoid process (Grisinger's symptom) can be a consequence of both thrombosis and perisinus abscess. Thrombosis of the bulb of the jugular vein is very rarely manifested in the form of a deficiency of IX–XII cranial nerves. Sometimes this lesion is a consequence of not a thrombosis, but a periphlebitis.
Cavernous sinus clot: Cavernous sinus thrombosis is a blood clot in the cavernous Might and might not: Cavernous sinus thrombosis can cause many symptoms such as.. If you have an autoimmune condition or are at a higher risk of developing blood clots, you should also be aware of signs of cavernous sinus thrombosis. The sooner you recognize the symptoms, the sooner you can start IV antibiotics and prevent the infection from spreading.Cavernous sinus thrombosis is a very serious condition that can be life-threatening. However, it’s also relatively rare. If you’ve recently had a severe head injury or an infection in your head, keep an eye out for any of the symptoms listed above.Doctors treat cavernous sinus thrombosis with high-dose antibiotics if they find an underlying infection. These are usually given through an IV drip.
With chronic otitis, thrombus metastases predominate in the lungs. Perhaps the retrograde spread of thrombus to the veins of the meninges that enter the transverse sinus with the formation of an abscess in the cerebellum or occipital lobe of the brain. Cerebral or cerebellar abscess can also occur with a suppurative thrombus by destroying the inner wall of the sinus and extending the process to the subarachnoid space and the brain tissue.Since many veins are midline structures, venous infarcts are often bilateral. This is seen in thrombosis of the superior sagittal sinus, straight sinus and the internal cerebral veins. Hypoplasia and aplasia of the right or left transverse sinus is a common finding. It can easily be mistaken for sinus thrombosis, because on the MRA one of the transverse sinuses is missing. When you suspect, that there is a hypoplastic transverse sinus, then you should look at the size of the jugular foramen. On the left images of a patient with hypoplasia of the left transverse sinus. Notice the size difference of the jugular foramen.Arachnoid granulations are small protrusions of the arachnoid through the dura mater. They protrude into the venous sinuses and may mimic filling defects caused by thrombus. Usually these granulations are easily to differentiate from thrombosis.
Some patients may need a ventricular peritoneal shunt procedure to keep the intracranial pressure normalized.The outer wall of the sigmoid sinus thickens and changes color. Wall of sigmoid sinus. From blue it becomes white or yellow-gray. Subsequently formed granulation or necrosis. If the operation is not performed in a timely manner, the inflammatory process extends to the inner endothelial layer of the sigmoid sinus wall.
People with severe symptoms caused by sinus thrombosis can be treated by an endovascular procedure in order to mechanically open the sinus or with the use of medications called thrombolitics.Sigmoid sinus Thrombosis is often limited, but it can sometimes spread retrograde to the transverse sinus until the venous sinuses merge or even the sinuses of the opposite side, and downwards to the bulb of the jugular vein and the jugular vein until the innominate vein. Possible spread of thrombosis into the upper and inferior petrosal and cavernous sinuses.Treatment should begin immediately and must be done in a hospital. A treatment plan could include:Cavernous sinus thrombosis is a serious condition that usually requires high doses of intravenous (IV) antibiotics often for several weeks. You may need to stay in the hospital while receiving IV antibiotics.
Sometimes patients are excited, euphoric, sometimes sluggish, apathetic. Due to circulatory disorders, infection of the brain tissue, there is an increase in intracranial pressure, changes in the fundus, focal brain symptoms. Possible concomitant meningitis or meningism as a result of toxic stimulation of the meninges.Symptoms of cerebral venous sinus thrombosis may vary, depending on the location of the thrombus. Responding quickly to these symptoms makes it more possible to recover.Your doctor will perform a physical exam and ask you about any symptoms you are experiencing. Symptoms of venous sinus thrombosis may include:On the left images of a patient with an infarction in the area of the vein of Labbe. On the non-enhanced images you can appreciate the dense thrombus within the transverse sinus and the hemorrhage in the infarcted area. On the enhanced images a filling defect can be seen in the transverse sinus. You can scroll through the images.
This chain of events is part of a stroke that can occur in adults and children. It can occur even in newborns and babies in the womb. A stroke can damage the brain and central nervous system. A stroke is serious and requires immediate medical attention.In infants the brain is usually less dense than in older children and adults. This results in a relative high density of the blood in the sagittal sinus compared to the brain, which simulates a dense clot sign.Sepsis in otitis sometimes has a prolonged course. In the past, the outcome was mostly fatal due to progressive heart weakness, lung gangrene, pyotorax or purulent meningitis, cerebral or cerebellar abscess. With the introduction of surgical treatment, and later sulfonamides and especially antibiotics most of the patients can be cured.Cavernous sinus thrombosis is a very rare but serious condition that involves a blood clot in your cavernous sinuses. The cavernous sinuses are hollow spaces located at the base of your brain and behind your eye sockets. They allow major veins to drain blood from your brain and face.