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Seroquel® Prolong should be taken before bedtime. The daily dose for the first 4 days of therapy is: 1st day - 50 mg, 2nd day - 100 mg, 3 days - 200 mg, 4th day - 300 mg. The recommended daily dose is 300 mg. Depending on the clinical effect and individual patient tolerance, the dose can be increased to 600 mg. The advantage of using Seroquel® Prolong in a daily dose of 600 mg compared with 300 mg was not revealed. Seroquel® Prolong in a dose exceeding 300 mg should be prescribed by a physician with experience in the therapy of bipolar disorders.Seroquel Prolong is used for the acute and maintenance treatment of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), mania (abnormally excited or irritated mood) and depression symptoms in bipolar disorder (maniac depression with unusual extreme mood swings) in adult patients. It is also used as an add-on therapy in major depressive disorders (a mood disorder that causes a persistent feeling of sadness and loss of interest, so much so that it interferes with normal daily activities).Disminución de la Hb, leucopenia, disminución del recuento de neutrófilos, aumento de eosinófilos; hiperprolactinemia, disminución de T<sub>4<\sub> total, descenso de T<sub>4<\sub> libre, disminución de T<sub>3<\sub> total, aumento de TSH; elevación de los niveles de triglicéridos séricos, elevación del colesterol total, disminución del colesterol HDL, aumento de peso, aumento del apetito, aumento de glucosa en sangre a niveles hiperglucémicos; sueños anormales y pesadillas, ideación y comportamiento suicida; somnolencia, mareo, cefalea, síncope, síntomas extrapiramidales, disartria; taquicardia, palpitaciones; visión borrosa; hipotensión ortostática; rinitis, disnea; sequedad de boca, estreñimiento, dispepsia, vómitos; elevación de las transaminasas séricas (ALT, AST), elevación de los niveles de gamma GT; síntomas de retirada, astenia leve, edema periférico, irritabilidad, pirexia.Tras la evaluación periodica de datos de farmacovigilancia se ha notificado erupción medicamentosa con eosinofilia y síntomas sistémicos (DRESS). Seroquel Prolong sisältää laktoosia, joka on eräänlainen sokeri. Jos lääkärisi on kertonut, että sinulla on jokin sokeri-intoleranssi Asteittainen lopettaminen vähintään 1-2 viikon aikana on suositeltavaa The general aim of this non interventional study is to clarify what are the current clinical treatment practices of Quetiapine Immediate Release and Quetiapine Extended Release

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